I'm building my story line around a rather sedate subject (a disability). I try to convince myself that good writing and a compelling narrative flow will win out even though the subject may not be exciting on the face. We can both name great books that tackled disabilities (Heart is a Lonely Hunter, Never Promised You a Rose Garden, etc), but most appear to be in decades past. If I'm jousting at windmills here, please just Snark me and put me out of my misery.
The Curious Incident of the Dog in the Night
and the novels listed here
The only thing I'm going to Snark you for is NOT having read Motherless Brooklyn, but trust me, the penalty for that oversight will be fully realized only after you've read the book and have seen what you've missed. Jon Letham is a superb novelist and really, you should just read everything he writes right now.