When Sylvie Berman gets sick and tired of her friend Margaret’s constant bragging about her perfect son, wonderful grandchildren and State Senator brother-in-law she takes matters into her own hands. When she finally coaxes her 45 year old, unmarried son to visit, a joke she plays turns out to be not so funny after all. After convincing herself that her son Jeffrey will never marry and have a family unless she changes his lifestyle, she falls for her own joke and signs him up to run for election to the US Senate, without his knowledge or consent.
One by one her retiree friends get dragged into the plot, which twists and turns its way through one roadblock after another, until Sylvie finds herself trapped in a web of her own making. When Jeffrey mistakenly believes she is on her death bed, she confesses what she has done. Now Jeffrey has to decide whether to grant what he believes is his mother’s dying wish and rise to the occasion, or find a way to get out of his meddling mother’s tangled web.
When Jeffrey reluctantly accepts the path his mother has laid before him, he does so with one stipulation; if he wins the primary, he’ll run for office; otherwise he goes back to his old job and the life he has made. As Jeffrey’s life starts unraveling before his eyes, a new, exciting and sometimes dangerous one unfolds before him.
Comic novels are comic when they take something real and blow it up to odd proportions, or turn expectations on their ear (to use a very helpful cliche).
Your premise fails here because you've over reached by making him a candidate for US Senate. First, you can't run for office unless you sign a declaration of candidacy and that requires the actual candidate's signature. Second, take a look at the amount of money he'd need.
This MIGHT work as a premise if she ran him for mayor, particularly in a smaller town. Or Sherrif (which would be kind of fun for threatening that bilious Margaret with the perfect family)
Who's the main characer? Jeffrey or Mom? Focus on one in the hook and tell us the dilemma that s/he faces.