Dear Miss Snark:
I've got a draft of a novel that is about to the point where I could use another pair of eyes to critique it. So I'm thinking of printing up a couple of copies for people I know and asking them to take a look at it, let me know what sucks about the book in the hopes I can fix things and make the book suck less before I send it out. Right now I don't have much of a plan besides sending it to people who read the genre and I can trust to be honest with me. Do you have any advice on this subject?
Yea, well, don't send it to me.
Particularly if we're friends.
Friends are useful for many things but beta reads isn't one of them. For starters, your friends are hardly ever going to say "you suck" and if they do, you need new friends.
You need what is called a critique group, or a writing group, or writing colleagues. These are people who have no vested interest in your Christmas card list, being cold shouldered by your mom, or uninvited to your wedding.
You also don't want to just say "what do you think of this". You need a list of questions starting with "when did you first lose interest in the plot" and "which character made you want to hurl".
Not that they will of course, but what you're looking for here are PROBLEMS not praise. Stuff the "you're the best thing since Jack Kerouac" crapraise, and focus on what's wrong. If they say nothing, they didn't read it.
You can have your friends and family read it later, when you are copy editing for the final draft before it's published. Grandmother Snark is still the best person on Planet Earth for finding spelling misstakes.