I got my query back from an agent. He had nothing but kind words to say of my manuscript but chose not to take on the work because he said it "offended his sensibilities." I did my homework on this fellow, and my manuscript is not the kind of thing that's outside his wheelhouse. He has a large number of sales in the literary genre, and a lot of novel that he represented are similar to my own.
Is offending an agent's sensibilities really reason to reject a work he obviously liked enough to comment so positively on? I mean, if Bret Easton Elis could get American Psycho looked at by an agent and published, I don't see how my novel is more offensive.
I'm an agent, you think I'm going to say no? Of course it's a reason to not take something on. I wouldn't take on anything that offended my sensibilities either. I'm pretty much offended by dead dogs, (KY "yea!!!"), the conspiracy of the Jews to rule the world, the conspiracy of the Catholics to rule the world and kill the Jews, the conspiracy of the ...well, you get the idea.
Finding an agent to represent your work means finding someone who WANTS your work to do well. You absolutely do not want an agent who's holding his nose every time he says the title of your book, so this guy did you a favor.
Bret Easton Ellis didn't launch his career on American Psycho either. And it was published fifteen years ago....not the best comparison for today's market.